EGIS® is Porcine derived ADM (Biologic mesh) for soft tissue reconstruction and reinforcement.

Regenerative Force

Muscle fascia repair with surgery can substantially be obtained in two ways: by applying inert reinforcement mesh or stimulating the body’s regenerative strength with biological prosthesis.


Regenerative surgery

REPAIR OF THE MUSCLE FASCIA with biological prostheses that are not artificially altered (not cross-linked) is based on biological processes which lead to the reconstruction of the missing fascia with tissue newly formed by the body itself. The mechanisms which the organism uses to regenerate natural biomaterial have been known for only a few decades:

  • Inflammation: the body’s initial reaction to the implant.
  • Regeneration: healing phase. Granulation tissue formation.
  • Remodelling: replacement of the biological prosthesis with new connective tissue.


Reparative surgery

THE REPAIR OF THE MUSCLE FASCIA with synthetic or cross-linked patches is based on the concepts of physical and mechanical resistance.

Synthetic patches and artificially modified biological patches (cross-linked) induce defence reactions in the body. After an initial inflammatory phase, these inert materials steer the organism’s healing process towards encapsulation of the implant.


Natural matrix, mechanical properties

Recent studies have demonstrated that early complications after biological matrix implant may depend on imperfect decellularisation of the matrix, and on the presence of cross-linked substances or preservatives.

The exclusive production process which EGIS® undergoes was developed in order to guarantee a completely natural product, not cross-linked, and without the presence of any chemicals which can amplify the inflammatory phenomenon and slow down the regular progression of tissue regeneration. 

Active natural matrix

Nowadays the concept of biocompatibility is not sufficient for securing the effectiveness of a biomaterial. Its performance must go beyond the threshold of passive tolerability. It must be active, not inert, in order to enhance the biological process of Guided Tissue Regeneration.

EGIS® originated as a completely natural product. It is composed of collagen obtained from porcine dermis which is fundamentally the same as human collagen.

EGIS® maintains the original structure and excellent mechanical resistance of proteins without needing induced structural modifications (cross-linking) thus providing immediate bioavailability.

As a natural extracellular matrix EGIS® maintains the structure of the pre-existing microvascular network. This allows the patient’s blood to easily permeate the matrix accelerating cell migration and tissue regeneration.

The structural alteration (cross-linking) of a biological matrix may lengthen the remodelling time or completely stop it significantly limiting cell migration.

The native protein structure gives EGIS® excellent mechanical properties able to fully withstand intra-abdominal pressure.

To guarantee the characteristics of EGIS® over time, the final phase of the production process includes freeze-drying to remove all liquids using exact pressure and temperature values.

This process makes the final product dry, excellent for correct storage at room temperature and which only requires simple rehydration before the implantation.


Indications, Protection and regeneration of soft tissues in thorax-abdominal sites

EGIS® maintains the original structure and excellent mechanical resistance of proteins without the need for chemical reinforcements (cross-linking) promoting tissue regeneration. Thoracic wall defects, which in the past were repaired with synthetic prostheses were not able to withstand infections, and are now widely treated with biological matrices.


Incisional hernia treatment

EGIS® can withstand pressures much higher than those exercised on the peritoneum, including when under strain. Its natural integrity means it can also be implanted in contact with the loops. The concept of using surgical mesh to repair hernias was introduced more than 50 years ago. Repair with biological prosthesis is now widely recognized as superior to repair with direct suturing or synthetic prostheses.


Prevention and treatment of parastomal hernia

The surgical treatment procedure for parastomal hernias is closing of the defect by direct suturing or reinforcement with prosthesis. The prophylactic use of surgical mesh to close the defect at the time of the stoma’s creation is now widespread to prevent the onset of new hernias. The synthetic mesh implant in these indications is not recommended due to the high risk of skin erosion and fistula formation.

In association with Negative Wound Pressure Therapy (NWPT)

When the defect is too extensive for a primary closing of the walls, NWPT therapy such as VAC is performed to allow healing of the wound by secondary intention by applying negative pressure to the site. EGIS® is indicated in association with this therapy, before the wound bed is ready for a skin graft which completes the closing.


Laparoscopic surgery

EGIS® is also available in 0.8 mm thickness. Its softness and malleability makes it easy to use in laparoscopic operations. EGIS® does not encounter any difficulties passing through a trocar and can be easily sutured with metallic or reabsorbable staples using common staplers.


Clinical outcome and anatomical-functional recovery

The choice of biomaterial has proven to be crucial for guiding tissue healing processes not just towards a positive clinical outcome, but also towards an anatomical-functional recovery.

EGIS® is a natural non-cross-linked matrix composed exclusively of porcine derived collagen (ADM-Acellular Dermal Matrix) which is fundamentally the same as human collagen. Thanks to its bioavailability it is recognised by the body as if it were part of it. It acts as an active in the granulation phase guiding healing towards long term clinical success (anatomical-functional recovery).

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